Cho Research Lab

We focus on developing and characterizing advanced drug delivery systems that improve "drug deliverability" and therapeutic/diagnostic efficacies.

 We successfully prepared Fibronectin CS1 peptide-conjugated poly(ethylene glycol)-block-poly(D, L-lactic acid) (FibCS1-PEG-b-PLA) micelles carrying Rapa, which were 98.08 ± 1.15 nm in particle size with a polydispersity index of 0.21 ± 0.01. In this study, we highlighted the feasibility of short-term intranasal administration of brain-targeting micelles carrying Rapa for improving cognitive behavior including motor coordination, recognition memory, and special learning and memory in an AD-bearing mouse model. 

Nano-based NIR fluorescence imaging for better tumor delineation has been established as a powerful tool to give surgeons real-time information about the location and margin of the tumor region by compensating the depth limitation. 

The nanogel pellet are shown to be stable as a pellet at ambient temperature, absorb water and change to a gel formulation at physiological temperature, and achieve gradual long-term release of the payloads. The in vivo testing in an orthotopic rodent models has shown an acceptable safety profile when implanted intracranially and a significant improvement in overall survival.

We aim to use a desktop FDM-based 3D printer to prototype portable medicine containers in a blister packet appearance with auxiliary braille flags that help validate early concepts and facilitate the conversation on refining product features in a rapid and affordable manner.